We are developing a new class of therapeutics targeting the effects of disease-driving sRNA isoforms

DISCOVERY PIPELINE OF THERAPEUTIC PROGRAMS FOCUS ON AREAS WITH KNOWN HETEROGENEITY

Inflammation
Inflammation
Fibrosis
Fibrosis
Neurodegeneration
Neurodegeneration

Gatehouse Bio has used its Code-Breaker™ Platform to analyze multiple diseases and identify hotspots where there is high isoform burden. These hotspots have created a portfolio of novel drug targets, each of which has relevance across several diseases, creating the opportunity for deep pipeline growth. Gatehouse Bio is currently developing its lead targets into biomarker-guided precision therapies for the treatment of pulmonary, cardiac, neurological, and autoimmune diseases. Code-Breaker’s capabilities can be applied to the discovery and design of oligonucleotide therapeutics for a significantly broader range of diseases than the company’s initial focus areas.

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We have established a global network of collaborators across academia, industry and patient advocacy groups who share our vision and commitment to patients.

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David Salzman, PhD

As founder and CEO of Gatehouse Bio, David has over 14 years of research expertise and experience in microRNA and sRNA biology. He is the force behind the science and technological development required for identifying sRNA diagnostics, targeted assay design, validation, and subsequent product development. He was previously a postdoctoral fellow at the Yale School of Medicine and a scientist at Biogen, where he gained experience in developing clinical and preclinincal biomarker, PK/PD, and diagnostic platforms. David also served as the CSO of MiraDx, spearheading projects to commercialize germline DNA biomarkers in oncology. He earned his PhD in Molecular Biology and Biochemistry from the University of Connecticut and a BS in Environmental Science from the University of Hartford.


View his publication record here.

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