Our AI-powered Code-Breaker™ platform interrogates small RNAs (sRNAs) isoform hotspots that drive heterogenous diseases
CODE-BREAKER CHARACTERIZES THE LANDSCAPE OF FUNCTIONAL sRNA ISOFORMS, MODELS THEIR ROLE IN DISEASE, IDENTIFIES PATIENT SUBSETS, AND DIGITALLY DESIGNS PRECISION DRUGS IN < ONE YEAR
BIOLOGY-INFLUENCED MACHINE LEARNING IDENTIFIES HOTSPOTS WHERE THERE IS HIGH ISOFORM BURDEN SHARED BETWEEN GROUPS OF PATIENTS WITHIN A DISEASE INDICATION
Platform analyzes millions of sRNA features to identify mutations that :
- Classifies disease
- Stratifies subjects
- Predicts disease drivers
- Designs biomarker-guided precision oligonucleotide therapies
OLIGONUCLEOTIDES TARGETING THE EFFECTS OF DISEASE-DRIVING sRNA ISOFORMS REPRESENT A NEW CLASS OF RNA THERAPEUTICS
sRNA therapeutics are delivered using lipid nanoparticles (LNPs) and conjugates
High fidelity therapeutics targeting sRNA isoforms enable unmatched precision
Advancements in LNP and conjugate chemistry enable drug delivery to specific tissue
SEMANTIC KNOWLEDGE GRAPH DISCOVERS COMMON HOTSPOTS WHERE THERE IS HIGH ISOFORM BURDEN ACROSS DISEASE INDICATIONS
Discover novel drugs that treat multiple indications
Repurpose existing compounds including small molecules, protacs, MABs
Introduce new combinational therapies
