Our platform interrogates small RNA to identify molecular drivers of disease
AI-DRIVEN DISCOVERY DEFINES MOLECULAR PROFILES OF DISEASE CALLED SRNA-SIGNATURES
Small RNA are master regulators of gene expression found in blood and tissue
SRNA-SIGNATURES CHARACTERIZE TARGETABLE PATHWAYS THAT ARE SHARED BETWEEN GROUPS OF PATIENTS WITHIN A DISEASE INDICATION
Platform analyzes millions of sRNA features to create a signature that:
Classifies disease
Stratifies subjects
Predicts disease drivers
Designs RNA therapeutics
TARGETING THE SRNA-SIGNATURE CREATES A NEW CLASS OF RNA THERAPEUTICS
sRNA therapeutics are delivered using lipid nanoparticles and conjugates
High fidelity therapeutics derived from the sRNA-signatures enable unmatched precision
Advancements in lipid nanoparticle and conjugate chemistry enable drug delivery to multiple tissues
MACHINE LEARNING MINES AN EXPANDING MULTI-OMICS DATABASE TO ESTABLISH A MAP OF COMMON PATHWAY TARGETS ACROSS INDICATIONS
Discover novel drugs that treat multiple indications
Repurpose existing compounds including small molecules, protacs, mabs
Introduce new combinational therapies
Next: A big opportunity with small RNA (sRNA)
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David Salzman, PhD
As founder and CEO of Gatehouse Bio, David has over 14 years of research expertise and experience in microRNA and sRNA biology. He is the force behind the science and technological development required for identifying sRNA diagnostics, targeted assay design, validation, and subsequent product development. He was previously a postdoctoral fellow at the Yale School of Medicine and a scientist at Biogen, where he gained experience in developing clinical and preclinincal biomarker, PK/PD, and diagnostic platforms. David also served as the CSO of MiraDx, spearheading projects to commercialize germline DNA biomarkers in oncology. He earned his PhD in Molecular Biology and Biochemistry from the University of Connecticut and a BS in Environmental Science from the University of Hartford.
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